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Models of Protocells Undergoing Asymmetrical Division.
Villani, Marco; Alboresi, Elena; Serra, Roberto.
Afiliação
  • Villani M; Department of Physics, Informatics and Mathematics, Modena and Reggio Emilia University, 41121 Modena, Italy.
  • Alboresi E; European Centre for Living Technology, 30123 Venice, Italy.
  • Serra R; Department of Physics, Informatics and Mathematics, Modena and Reggio Emilia University, 41121 Modena, Italy.
Entropy (Basel) ; 26(4)2024 Mar 26.
Article em En | MEDLINE | ID: mdl-38667835
ABSTRACT
The conditions that allow for the sustained growth of a protocell population are investigated in the case of asymmetrical division. The results are compared to those of previous studies concerning models of symmetrical division, where synchronization (between duplication of the genetic material and fission of the lipid container) was found under a variety of different assumptions about the kinetic equations and about the place where molecular replication takes place. Such synchronization allows a sustained proliferation of the protocell population. In the asymmetrical case, there can be no true synchronization, since the time to duplication may depend upon the initial size, but we introduce a notion of homogeneous growth that actually allows for the sustained reproduction of a population of protocells. We first analyze Surface Reaction Models, defined in the text, and we show that in many cases they undergo homogeneous growth under the same kinetic laws that lead to synchronization in the symmetrical case. This is the case also for Internal Reaction Models (IRMs), which, however, require a deeper understanding of what homogeneous growth actually means, as discussed below.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article