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Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.
Sarges, Kevin Matheus Lima de; Póvoa da Costa, Flávia; Santos, Erika Ferreira Dos; Cantanhede, Marcos Henrique Damasceno; da Silva, Rosilene; Veríssimo, Adriana de Oliveira Lameira; Viana, Maria de Nazaré do Socorro de Almeida; Rodrigues, Fabíola Brasil Barbosa; Leite, Mauro de Meira; Torres, Maria Karoliny da Silva; Bentes da Silva, Christiane; Brito, Mioni Thieli Figueiredo Magalhães de; Silva, Andréa Luciana Soares da; Henriques, Daniele Freitas; Vallinoto, Izaura Maria Vieira Cayres; Viana, Giselle Maria Rachid; Queiroz, Maria Alice Freitas; Vallinoto, Antonio Carlos Rosário; Santos, Eduardo José Melo Dos.
Afiliação
  • Sarges KML; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Póvoa da Costa F; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Santos EFD; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Cantanhede MHD; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • da Silva R; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Veríssimo AOL; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Viana MNDSA; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Rodrigues FBB; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Leite MM; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Torres MKDS; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Bentes da Silva C; Center for Biological Health Sciences, State University of Pará, Tucuruí 68455-210, Brazil.
  • Brito MTFM; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Silva ALSD; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Henriques DF; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Vallinoto IMVC; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Viana GMR; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
  • Queiroz MAF; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Vallinoto ACR; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.
  • Santos EJMD; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.
Viruses ; 16(4)2024 04 22.
Article em En | MEDLINE | ID: mdl-38675991
ABSTRACT
Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV 13.51% vs. CG 6.30%; p = 0.003) and the *T allele (CoV 33.56% vs. CG 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon gama / Predisposição Genética para Doença / SARS-CoV-2 / COVID-19 / Genótipo Limite: Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon gama / Predisposição Genética para Doença / SARS-CoV-2 / COVID-19 / Genótipo Limite: Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article