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Serum cystatin C and stroke risk: a national cohort and Mendelian randomization study.
Qi, Yitian; Shang, Xinyun; Han, Tianjiao; Han, Ning; Jiang, Ziwei; Yan, Han; Yue, Siqi; Sun, Qichao; Liu, Lin; Cui, Cancan.
Afiliação
  • Qi Y; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Shang X; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Han T; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Han N; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Jiang Z; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Yan H; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Yue S; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Sun Q; The First Bethune Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Liu L; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
  • Cui C; China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Front Endocrinol (Lausanne) ; 15: 1355948, 2024.
Article em En | MEDLINE | ID: mdl-38681764
ABSTRACT

Purpose:

The debate over the causal and longitudinal association between cystatin C and stroke in older adults persists. Our aim was to assess the link between cystatin C levels, both measured and genetically predicted, and stroke risk.

Methods:

This study employed a retrospective cohort design using samples of the China Health and Retirement Longitudinal Study (CHARLS), which is a nationally representative cohort recruiting individuals aged 45 years or above. A multivariate logistic model and the two-sample Mendelian randomization framework were used to investigate the longitudinal and genetically predicted effect of serum cystatin C on stroke.

Results:

The study population had a mean age of 59.6 (SD ±9.5), with 2,996 (46.1%) women. After adjusting for confounding factors, compared to those in the first quartile of cystatin C, those in the last quartile had the greatest risk of stroke incidence [odds ratio (OR), 1.380; 95% confidence interval (CI), 1.046-1.825]. The Mendelian randomization analysis showed that a genetically predicted cystatin C level was positively associated with total stroke (OR by inverse variance-weighted method, 1.114; 95% CI, 1.041-1.192).

Conclusions:

This national cohort study suggests that higher serum cystatin C is associated with an increased risk of total stroke, which is further supported by Mendelian randomization.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Cistatina C / Análise da Randomização Mendeliana Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Cistatina C / Análise da Randomização Mendeliana Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2024 Tipo de documento: Article