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The role of innate lymphoid cells in systemic lupus erythematosus.
Chen, Yong; Gu, Xiaotian; Cao, Kunyu; Tu, Miao; Liu, Wan; Ju, Jiyu.
Afiliação
  • Chen Y; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China.
  • Gu X; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China.
  • Cao K; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China.
  • Tu M; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China.
  • Liu W; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China. Electronic address: liuwan@sdsmu.edu.cn.
  • Ju J; School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China. Electronic address: jujiyu@163.com.
Cytokine ; 179: 156623, 2024 07.
Article em En | MEDLINE | ID: mdl-38685155
ABSTRACT
Systemic lupus erythematosus (SLE) is a connective tissue disorder that affects various body systems. Both the innate and adaptive immunity contribute to the onset and progression of SLE. The main mechanism of SLE is an excessive immune response of immune cells to autoantigens, which leads to systemic inflammation and inflammation-induced organ damage. Notably, a subset of innate immune cells known as innate lymphoid cells (ILCs) has recently emerged. ILCs are pivotal in the early stages of infection; participate in immune responses, inflammation, and tissue repair; and regulate the immune function of the body by resisting pathogens and regulating autoimmune inflammation and metabolic homeostasis. Thus, ILCs dysfunction can lead to autoimmune diseases. This review discusses the maturation of ILCs, the potential mechanisms by which ILCs exacerbate SLE pathogenesis, and their contributions to organ inflammatory deterioration in SLE.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Imunidade Inata / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos / Imunidade Inata / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article