Real-world experience with filgotinib for rheumatoid arthritis in Germany : A retrospective chart review.
Z Rheumatol
; 2024 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-38689038
ABSTRACT
BACKGROUND:
Real-world data for filgotinib, a Janus kinase (JAK)1 inhibitor, are limited in patients with rheumatoid arthritis (RA).OBJECTIVES:
To explore real-world filgotinib use in patients with RA in Germany. MATERIALS ANDMETHODS:
This retrospective chart review included patients aged ≥â¯18 years with confirmed moderate to severe RA who initiated filgotinib before December 1, 2021, with ≥â¯6 months of medical records available prior to filgotinib initiation or after initial diagnosis. Patient characteristics, prior treatments, reasons for initiating/discontinuing filgotinib, disease activity, dose adjustments and concomitant treatments were recorded.RESULTS:
In total, 301 patients from 20 German rheumatology outpatient units were included. One-third were aged ≥â¯65 years and almost half had ≥â¯1 cardiovascular (CV) risk factor. Most patients initiated filgotinib as monotherapy (83.7%; 12.7% of whom with glucocorticoids) and at the 200â¯mg dose (84.7%); higher proportions of those initiating the 100 versus 200â¯mg dose were aged ≥â¯65 years and had renal impairment or ≥â¯1 CV risk factor. Oral administration (78.4%), fast onset of action (66.8%) and administration as monotherapy (65.4%) were the most common reasons for initiating filgotinib. At 12 months, 41 (18.4%) patients had discontinued filgotinib, most commonly due to lack of effectiveness. After 6months of follow-up, 36.8% of patients had achieved Clinical Disease Activity Index (CDAI) remission and 45.6% had achieved CDAI low disease activity.CONCLUSIONS:
In clinical practice in Germany, reasons for initiating filgotinib in patients with RA were related to dosing flexibility and general JAK inhibitor attributes. Filgotinib was used predominantly as monotherapy and was effective and generally well tolerated; however, longer-term data in larger, prospective cohorts are needed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article