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Extended-Gate FET Biosensor Based on GaN Micropillar Array and Polycrystalline Layer: Application to Hg2+ Detection in Human Urine.
Zhou, Jialing; Huang, Hui; Wang, Qian; Li, Zhirui; Chen, Shunji; Yu, Jun; Zhong, Yuan; Chen, Jing; Huang, Huolin.
Afiliação
  • Zhou J; School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, China.
  • Huang H; School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, China.
  • Wang Q; School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, China.
  • Li Z; School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, China.
  • Chen S; School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, China.
  • Yu J; School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, China.
  • Zhong Y; School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian 116024, China.
  • Chen J; Center for Advanced Measurement Science, National Institute of PR Metrology, Beijing 100029, China.
  • Huang H; Electrical & Electronic Experimental Center, Dalian University of Technology, Dalian 116024, China.
Anal Chem ; 96(19): 7577-7584, 2024 05 14.
Article em En | MEDLINE | ID: mdl-38696338
ABSTRACT
Owing to the separation of field-effect transistor (FET) devices from sensing environments, extended-gate FET (EGFET) biosensor features high stability and low cost. Herein, a highly sensitive EGFET biosensor based on a GaN micropillar array and polycrystalline layer (GMP) was fabricated, which was prepared by using simple one-step low-temperature MOCVD growth. In order to improve the sensitivity and detection limit of EGFET biosensor, the surface area and the electrical conductivity of extended-gate electrode can be increased by the micropillar array and the polycrystalline layer, respectively. The designed GMP-EGFET biosensor was modified with l-cysteine and applied for Hg2+ detection with a low limit of detection (LOD) of 1 ng/L, a high sensitivity of -16.3 mV/lg(µg/L) and a wide linear range (1 ng/L-24.5 µg/L). In addition, the detection of Hg2+ in human urine was realized with an LOD of 10 ng/L, which was more than 30 times lower than that of reported sensors. To our knowledge, it is the first time that GMP was used as extended-gate of EGFET biosensor.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Limite de Detecção / Mercúrio Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Limite de Detecção / Mercúrio Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article