Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis.
Mol Cell
; 84(9): 1635-1636, 2024 May 02.
Article
em En
| MEDLINE
| ID: mdl-38701740
ABSTRACT
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ubiquitinação
/
Homeostase
/
Nucleotidiltransferases
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article