Is Lyophilization Key for Transportation and Storage of Biopharmaceutical Drug Products in Space?
J Pharm Sci
; 113(7): 1695-1700, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38701895
ABSTRACT
Long-lasting space missions as well as space tourism are technically possible today and economically in reach. It is a matter of time until the use of biopharmaceutical drug products in space will be common practice. Until drug product manufacturing in space is possible, the products need to be brought to space with rockets, which means that stable and light-weight products are preferred. Lyophilization is a promising approach to reduce weight during transportation and achieve storage stability at room temperature without cold-chain demands. This implies that recycled water in space needs to be used for reconstitution which poses a microbiological challenge and should be considered during formulation development. Furthermore, administration of the injectable drugs in space has an impact on the chosen packaging material which needs to be considered during drug product development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meios de Transporte
/
Estabilidade de Medicamentos
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Armazenamento de Medicamentos
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Liofilização
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article