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Tumor-infiltrating lymphocytes as a predictor of axillary and primary tumor pathological response after neoadjuvant chemotherapy in patients with breast cancer: a retrospective cohort study.
Chin, Kian; Landén, Amalia H; Kovács, Anikó; Wärnberg, Fredrik; Ekholm, Maria; Karlsson, Per; Olofsson Bagge, Roger.
Afiliação
  • Chin K; Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden. kian.chin@vgregion.se.
  • Landén AH; Department of Surgery, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden. kian.chin@vgregion.se.
  • Kovács A; Department of Oncology, Institute of Clinical Sciences in Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Wärnberg F; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Ekholm M; Institute of Clinical Sciences, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.
  • Karlsson P; Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.
  • Olofsson Bagge R; Department of Biomedical and Clinical Sciences, Division of Oncology, Linköping University, Linköping, Sweden.
Breast Cancer Res Treat ; 207(1): 49-63, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38703286
ABSTRACT

PURPOSE:

Tumor-infiltrating lymphocytes (TILs) can predict complete pathological response (pCR) of tumor in the breast but not so well-defined in the axilla after neoadjuvant chemotherapy. Since axillary surgery is being increasingly de-escalated after NACT, we aimed to investigate the relationship between TILs and pCR in the axilla and breast, as well as survival amongst NACT patients.

METHODS:

Clinicopathological data on patients who underwent NACT between 2013 and 2020 were retrospectively examined. Specifically, pre-TILs (before NACT), post-TILs (after NACT) and ΔTIL (changes in TILs) were assessed. Primary endpoint was pCR and secondary endpoints were breast cancer-free interval (BCFI) and overall survival (OS).

RESULTS:

Two hundred and twenty patients with nodal metastases were included. Overall axillary and breast pCR rates were 42.7% (94/220) and 39.1% (86/220), respectively, whereas the combined pCR rate was 32.7% (72/220). High pre-TILs (OR 2.03, 95% CI 1.02-4.05; p = 0.04) predicted axillary pCR whereas, high post-TILs (OR 0.33, 95% CI 0.14-0.76; p = 0.009) and increased ΔTILs (OR 0.25, 95% CI 0.08-0.79; p = 0.02) predicted non-axillary pCR. TILs were not a significant predictor for BCFI and OS.

CONCLUSIONS:

This study supports the potential use of pre-TILs to select initially node-positive patients for axillary surgical de-escalation after NACT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Axila / Neoplasias da Mama / Linfócitos do Interstício Tumoral / Terapia Neoadjuvante Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Axila / Neoplasias da Mama / Linfócitos do Interstício Tumoral / Terapia Neoadjuvante Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article