Improving in vivo assays in snake venom and antivenom research: A community discussion.
F1000Res
; 13: 192, 2024.
Article
em En
| MEDLINE
| ID: mdl-38708289
ABSTRACT
On the 26 th January 2023, a free to attend, 'improving in vivo snake venom research a community discussion' meeting was held virtually. This webinar brought together researchers from around the world to discuss current neutralisation of venom lethality mouse assays that are used globally to assess the efficacy of therapies for snakebite envenoming. The assay's strengths and weaknesses were highlighted, and we discussed what improvements could be made to refine and reduce animal testing, whilst supporting preclinical antivenom and drug discovery for snakebite envenoming. This report summarises the issues highlighted, the discussions held, with additional commentary on key perspectives provided by the authors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mordeduras de Serpentes
/
Venenos de Serpentes
/
Antivenenos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article