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Intraoperative quantitative crystalline lens nuclear opacities analysis based on crystalline lenSx platform.
Zhang, Ying; Zhang, Yaya; Zhang, Junting; Wang, Tao; Yi, Luhui; Zeng, Yao; Zeng, Guorong; Kong, Lingdong; Ye, Bo; Yi, Yunmin.
Afiliação
  • Zhang Y; Department of Ophthalmology, Jiangxi Provincial Hospital of Integrated Chinese and Western Medicine, the Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330003, China.
  • Zhang Y; Nanchang Aier Eye Hospital, Nanchang, 330006, China.
  • Zhang J; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Wang T; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Yi L; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Zeng Y; The Fourth Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Zeng G; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Kong L; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
  • Ye B; Nanchang Aier Eye Hospital, Nanchang, 330006, China. yebo814@126.com.
  • Yi Y; Affiliated Eye Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. yiyunmin0528@126.com.
BMC Ophthalmol ; 24(1): 206, 2024 May 06.
Article em En | MEDLINE | ID: mdl-38711059
ABSTRACT

PURPOSE:

The main objective is to quantify the lens nuclear opacity using spectral-domain optical coherence tomography (SD-OCT) and to evaluate its association with Lens Opacities Classification System III (LOCS-III) system, lens thickness (LT), and surgical parameters. The secondary objective is to assess the diagnostic model performance for hard nuclear cataract.

METHODS:

This study included 70 eyes of 57 adults with cataract, with 49 (70%) and 21 (30%) in training and validation cohort, respectively. Correlations of the average nuclear density (AND) /maximum nuclear density (MND) with LOCS-III scores, LT, and surgical parameters were analyzed. Univariate and multivariate logistic regression analysis, receiver operating characteristic curves and calibration curves were performed for the diagnostic of hard nuclear cataract.

RESULTS:

The pre-operative uncorrected distance visual acuity (UDVA), intraocular pressure (IOP), mean axial length (AL), and LT were 1.20 ± 0.47 log MAR, 15.50 ± 2.87 mmHg, 27.34 ± 3.77 mm and 4.32 ± 0.45 mm, respectively. The average nuclear opalescence (NO) and nuclear colour (NC) scores were 3.61 ± 0.94 and 3.50 ± 0.91 (ranging from 1.00 to 6.90), respectively. The average AND and MND were 137.94 ± 17.01 and 230.01 ± 8.91, respectively. NC and NO scores both significantly correlated with the AND (rNC = 0.733, p = 0.000; rNO = 0.755, p = 0.000) and MND (rNC = 0.643, p = 0.000; rNO = 0.634, p = 0.000). In the training cohort, the area under the curve (AUC) of the model was 0.769 (P < 0.001, 95%CI 0.620-0.919), which had a good degree of differentiation (Fig. 2a). The calibration curve showed good agreement between predicted and actual probability.

CONCLUSION:

The nuclear density measurement on SD-OCT images can serve as an objective and reliable indicator for quantifying nuclear density.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catarata / Acuidade Visual / Tomografia de Coerência Óptica / Núcleo do Cristalino Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catarata / Acuidade Visual / Tomografia de Coerência Óptica / Núcleo do Cristalino Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article