Reversal of gamma-radiation-induced leukemogenesis in mice by immunomodulation with thiabendazole and dinitrofluorobenzene.
J Natl Cancer Inst
; 74(4): 811-5, 1985 Apr.
Article
em En
| MEDLINE
| ID: mdl-3872957
ABSTRACT
The effect of thiabendazole (TBZ) and dinitrofluorobenzene (DNFB) on radiation-induced leukemogenesis was investigated in the C57BL/6 mouse model. Administration of TBZ-DNFB during, post, or during and post irradiation successfully blocked leukemogenesis, as indicated by the absence of leukemia blast cells in thymus and peripheral blood, as well as prevented thymic lymphoma. TBZ-DNFB treatment prevented the development of leukemia when studies were terminated both after 7 months of last irradiation (disease fully developed) and after 5 months of last irradiation (disease in the process of development). This TBZ-DNFB treatment also resulted in a significant increase in survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiabendazol
/
Leucemia Induzida por Radiação
/
Dinitrofluorbenzeno
/
Nitrobenzenos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article