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Rapid expansion and international spread of M1UK in the post-pandemic UK upsurge of Streptococcus pyogenes.
Vieira, Ana; Wan, Yu; Ryan, Yan; Li, Ho Kwong; Guy, Rebecca L; Papangeli, Maria; Huse, Kristin K; Reeves, Lucy C; Soo, Valerie W C; Daniel, Roger; Harley, Alessandra; Broughton, Karen; Dhami, Chenchal; Ganner, Mark; Ganner, Marjorie A; Mumin, Zaynab; Razaei, Maryam; Rundberg, Emma; Mammadov, Rufat; Mills, Ewurabena A; Sgro, Vincenzo; Mok, Kai Yi; Didelot, Xavier; Croucher, Nicholas J; Jauneikaite, Elita; Lamagni, Theresa; Brown, Colin S; Coelho, Juliana; Sriskandan, Shiranee.
Afiliação
  • Vieira A; Department of Infectious Disease, Imperial College London, London, UK.
  • Wan Y; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Ryan Y; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.
  • Li HK; Department of Infectious Disease, Imperial College London, London, UK.
  • Guy RL; NIHR Health Protection Research Unit in Healthcare-associated Infections and AMR, Imperial College London, London, UK.
  • Papangeli M; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK.
  • Huse KK; Reference Services Division, UK Health Security Agency, London, UK.
  • Reeves LC; Department of Infectious Disease, Imperial College London, London, UK.
  • Soo VWC; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Daniel R; Healthcare-Associated Infections, Fungal, AMR, AMU, and Sepsis Division, UK Health Security Agency, London, UK.
  • Harley A; Department of Infectious Disease, Imperial College London, London, UK.
  • Broughton K; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Dhami C; Department of Infectious Disease, Imperial College London, London, UK.
  • Ganner M; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Ganner MA; Department of Infectious Disease, Imperial College London, London, UK.
  • Mumin Z; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Razaei M; Department of Infectious Disease, Imperial College London, London, UK.
  • Rundberg E; Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
  • Mammadov R; Reference Services Division, UK Health Security Agency, London, UK.
  • Mills EA; Reference Services Division, UK Health Security Agency, London, UK.
  • Sgro V; Reference Services Division, UK Health Security Agency, London, UK.
  • Mok KY; Reference Services Division, UK Health Security Agency, London, UK.
  • Didelot X; Reference Services Division, UK Health Security Agency, London, UK.
  • Croucher NJ; Reference Services Division, UK Health Security Agency, London, UK.
  • Jauneikaite E; Reference Services Division, UK Health Security Agency, London, UK.
  • Lamagni T; Reference Services Division, UK Health Security Agency, London, UK.
  • Brown CS; Reference Services Division, UK Health Security Agency, London, UK.
  • Coelho J; Reference Services Division, UK Health Security Agency, London, UK.
  • Sriskandan S; Department of Infectious Disease, Imperial College London, London, UK.
Nat Commun ; 15(1): 3916, 2024 May 10.
Article em En | MEDLINE | ID: mdl-38729927
ABSTRACT
The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1UK to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1global strains, invasive M1UK strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1UK is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1UK clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1UK isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1UK point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Infecções Estreptocócicas / Streptococcus pyogenes / COVID-19 Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Infecções Estreptocócicas / Streptococcus pyogenes / COVID-19 Limite: Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article