Towards non-invasive tissue hydration measurements with optical coherence tomography.
J Biophotonics
; 17(7): e202300532, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38735734
ABSTRACT
The attenuation coefficient ( µ OCT ) measured by optical coherence tomography (OCT) has been used to determine tissue hydration. Previous dual-wavelength OCT systems could not attain the needed precision, which we attribute to the absence of wavelength-dependent scattering of tissue in the underlying model. Assuming that scattering can be described using two parameters, we propose a triple/quadrupole-OCT system to achieve clinically relevant precision in water volume fraction. In this study, we conduct a quantitative analysis to determine the necessary precision of µ OCT measurements and compare it with numerical simulation. Our findings emphasize that achieving a clinically relevant assessment of a 2% water fraction requires determining the attenuation coefficient with a remarkable precision of 0.01 m m - 1 . This precision threshold is influenced by the chosen wavelength for attenuation measurement and can be enhanced through the inclusion of a fourth wavelength range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Água
/
Tomografia de Coerência Óptica
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article