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The subcommissural organ regulates brain development via secreted peptides.
Zhang, Tingting; Ai, Daosheng; Wei, Pingli; Xu, Ying; Bi, Zhanying; Ma, Fengfei; Li, Fengzhi; Chen, Xing-Jun; Zhang, Zhaohuan; Zou, Xiaoxiao; Guo, Zongpei; Zhao, Yue; Li, Jun-Liszt; Ye, Meng; Feng, Ziyan; Zhang, Xinshuang; Zheng, Lijun; Yu, Jie; Li, Chunli; Tu, Tianqi; Zeng, Hongkui; Lei, Jianfeng; Zhang, Hongqi; Hong, Tao; Zhang, Li; Luo, Benyan; Li, Zhen; Xing, Chao; Jia, Chenxi; Li, Lingjun; Sun, Wenzhi; Ge, Woo-Ping.
Afiliação
  • Zhang T; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Ai D; Chinese Institute for Brain Research, Beijing, China.
  • Wei P; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Xu Y; Chinese Institute for Brain Research, Beijing, China.
  • Bi Z; Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
  • Ma F; School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
  • Li F; State Key Laboratory of Proteomics, National Center for Protein Sciences-Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
  • Chen XJ; Chinese Institute for Brain Research, Beijing, China.
  • Zhang Z; College of Life Sciences, Nankai University, Tianjin, China.
  • Zou X; Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
  • Guo Z; Chinese Institute for Brain Research, Beijing, China.
  • Zhao Y; State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
  • Li JL; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Ye M; Chinese Institute for Brain Research, Beijing, China.
  • Feng Z; Department of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
  • Zhang X; Chinese Institute for Brain Research, Beijing, China.
  • Zheng L; Changping Laboratory, Beijing, China.
  • Yu J; Chinese Institute for Brain Research, Beijing, China.
  • Li C; Chinese Institute for Brain Research, Beijing, China.
  • Tu T; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
  • Zeng H; Chinese Institute for Brain Research, Beijing, China.
  • Lei J; Chinese Institute for Brain Research, Beijing, China.
  • Zhang H; Changping Laboratory, Beijing, China.
  • Hong T; School of Basic Medical Sciences, Capital Medical University, Beijing, China.
  • Zhang L; Chinese Institute for Brain Research, Beijing, China.
  • Luo B; Chinese Institute for Brain Research, Beijing, China.
  • Li Z; Chinese Institute for Brain Research, Beijing, China.
  • Xing C; School of Basic Medical Sciences, Capital Medical University, Beijing, China.
  • Jia C; Chinese Institute for Brain Research, Beijing, China.
  • Li L; Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
  • Sun W; National Institute of Biological Sciences, Beijing, China.
  • Ge WP; Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, Beijing, China.
Nat Neurosci ; 27(6): 1103-1115, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38741020
ABSTRACT
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes, Sspo, Car3 and Spdef, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Órgão Subcomissural / Encéfalo Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Órgão Subcomissural / Encéfalo Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article