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Lineage 1 PRRSVs infection induces hemorrhagic injury in intestines of piglets: Effects on complement and coagulation cascades.
Zhao, Yongxin; Wang, Ruiqing; Li, Wei; Ren, Guofan; Zhang, Yining; Guo, Ruhai; Zhang, Xiao; Zhang, Jingnan; Li, Junda; Yu, Chenfei; Hu, Ruochen; Zhang, Riteng; Yang, Zengqi; Zeshan, Basit; Zhou, Yefei; Wang, Xinglong.
Afiliação
  • Zhao Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Wang R; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Li W; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Ren G; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Zhang Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Guo R; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Zhang X; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Zhang J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Li J; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Yu C; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Hu R; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Zhang R; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Yang Z; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
  • Zeshan B; Faculty of Sustainable Agriculture, University Malaysia Sabah, Sandakan, Sabah, Malaysia.
  • Zhou Y; Department of Life Science, Nanjing Xiaozhuang University, Jiangsu, Nanjing, 211171, China. Electronic address: yfzhou@njxzc.edu.cn.
  • Wang X; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: wxlong@nwsuaf.edu.cn.
Microb Pathog ; 192: 106682, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38750776
ABSTRACT
Porcine reproductive and respiratory syndrome virus (PRRSV) causes a highly transmissible disease of significant concern in the pig industry. Previous studies have demonstrated that the XM-2020 strain (a lineage 1.8 PRRSV IA/2012/NADC30) can induce special hemorrhagic injury in the small intestines. However, the specific mechanism underlying this injurious effect remains incompletely understood. In this study, we examined the pathogenic properties of XM-2020 and YC-2020 strains (a lineage 1.5 PRRSV IA/2014/NADC34) in piglets. Animal pathogenic tests revealed that with either Lineage 1 PRRSVs strains XM-2020 or YC-2020 demonstrated pronounced intestinal hemorrhage and suppression of peripheral immunological organs, comparing to JXA1 infection. Transcriptome analysis of diseased small intestines unveiled that PRRSV infection stimulated oxidative and inflammatory reactions. Remarkably, we also observed activation of the complement system alongside a notable down-regulation of complement and coagulation cascade pathways in the Lineage 1 PRRSVs infection group. Based on these findings, we propose that the primary mechanism driving the hemorrhagic injury of the small intestine caused by Lineage 1 PRRSVs is the suppression of complement and coagulation cascades resulting from immunosuppression. This discovery deepens our understanding of the pathogenicity of PRRSV in the small intestine and provides promising ways out for the development of innovative strategies aimed at controlling PRRSV.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Sistema Complemento / Vírus da Síndrome Respiratória e Reprodutiva Suína / Síndrome Respiratória e Reprodutiva Suína Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Sistema Complemento / Vírus da Síndrome Respiratória e Reprodutiva Suína / Síndrome Respiratória e Reprodutiva Suína Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article