Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux.
J Asian Nat Prod Res
; 26(8): 900-909, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38753580
ABSTRACT
Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Euphorbia
/
Diterpenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article