Drivers of Memory Loss Underreport in Mild Cognitive Impairment Due to Alzheimer Versus Vascular Disease.
Alzheimer Dis Assoc Disord
; 38(2): 128-132, 2024.
Article
em En
| MEDLINE
| ID: mdl-38755756
ABSTRACT
BACKGROUND:
We examined drivers of self and study partner reports of memory loss in mild cognitive impairment (MCI) from Alzheimer (AD-MCI) and vascular disease (Va-MCI).METHODS:
We performed retrospective cross-sectional analyses of participants with AD-MCI (n=2874) and Va-MCI (n=376) from the National Alzheimer Coordinating Center data set. Statistical analysis utilized 2-sided t test or the Fisher exact test.RESULTS:
Compared with AD-MCI, Va-MCI subjects (24.5% vs. 19.7%, P =0.031) and study partners (31.4% vs. 21.6%, P <0.0001) were more likely to deny memory loss. Black/African Americans were disproportionately represented in the group denying memory loss in AD-MCI (20.0% vs. 13.2%, P <0.0001) and Va-MCI (33.7% vs. 18.0%, P =0.0022). Study partners of participants with these features also disproportionately denied memory loss female (AD-MCI 60.1% vs. 51.7%, P =0.0002; Va-MCI 70.3% vs. 52.3%, P =0.0011), Black/African American (AD-MCI 23.5% vs. 11.98%, P <0.0001; Va-MCI 48.8% vs. 26.5%, P =0.0002), and <16 years of education (AD-MCI only 33.9% vs. 16.3%, P =0.0262). In AD-MCI and Va-MCI, participants with anxiety were disproportionately represented in the group endorsing memory loss (AD 28.2% vs. 17.4%, P <0.0001; Va 31.5% vs. 16.1%, P =0.0071), with analogous results with depression.CONCLUSION:
The findings would suggest extra vigilance in interview-based MCI detection of persons at-risk for self-based or informant-based misreport.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Doença de Alzheimer
/
Disfunção Cognitiva
/
Transtornos da Memória
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article