DNA-damage RBE assessment for combined boron and gadolinium neutron capture therapy.
J Appl Clin Med Phys
; 25(7): e14399, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38767333
ABSTRACT
PURPOSE:
Neutron capture therapy (NCT) by 10B and 157Gd agents is a unique irradiation-based method which can be used to treat brain tumors. Current study aims to quantitatively evaluate the relative biological effectiveness (RBE) and dose distributions during the combined BNCT and GdNCT modalities through a hybrid Monte Carlo (MC) simulation approach.METHODS:
Snyder head phantom as well as a cubic hypothetical tumor was at first modeled by Geant4 MC Code. Then, the energy spectra and dose distribution relevant to the released secondary particles during the combined Gd/BNCT were scored for different concentrations of 157Gd and 10B inside tumor volume. Finally, the scored energy spectra were imported to the MCDS code to estimate both RBESSB and RBEDSB values for different 157Gd concentrations.RESULTS:
The results showed that combined Gd/BNCT increases the fluence-averaged RBESSB values by about 1.7 times when 157Gd concentration increments from 0 to 2000 µg/g for both considered cell oxygen levels (pO2 = 10% and 100%). Besides, a reduction of about 26% was found for fluence-averaged RBEDSB values with an increment of 157Gd concentration in tumor volume.CONCLUSION:
From the results, it can be concluded that combined Gd/BNCT technique can improve tumor coverage with higher dose levels but in the expense of RBEDSB reduction which can affect the clinical efficacy of the NCT technique.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dosagem Radioterapêutica
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Eficiência Biológica Relativa
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Dano ao DNA
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Neoplasias Encefálicas
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Método de Monte Carlo
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Terapia por Captura de Nêutron de Boro
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Imagens de Fantasmas
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Gadolínio
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article