Breaking through the treatment desert of conventional mesothelin-targeted CAR-T cell therapy for malignant mesothelioma: A glimpse into the future.

Wang, Yuning; Zhao, Guo; Xing, Shujun; Wang, Shuhang; Li, Ning

Wang, Yuning; Zhao, Guo; Xing, Shujun; Wang, Shuhang; Li, Ning.

Afiliação

Wang Y; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhao G; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Xing S; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Wang S; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: snowflake201@gmail.com.
Li N; Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: lining@cicams.ac.cn.

Pharmacol Res ; 204: 107220, 2024 Jun.

Article em En | MEDLINE | ID: mdl-38768670

Assuntos

Proteínas Ligadas por GPI; Imunoterapia Adotiva; Mesotelina; Mesotelioma Maligno; Receptores de Antígenos Quiméricos; Humanos; Imunoterapia Adotiva/métodos; Mesotelioma Maligno/terapia; Receptores de Antígenos Quiméricos/imunologia; Receptores de Antígenos Quiméricos/metabolismo; Proteínas Ligadas por GPI/antagonistas & inibidores; Proteínas Ligadas por GPI/metabolismo; Animais; Neoplasias Pulmonares/terapia

Palavras-chave

CAR-T cell therapy; Clinical trial landscape; Combined therapy; Malignant mesothelioma; Mesothelin; Novel target discovery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Proteínas Ligadas por GPI / Receptores de Antígenos Quiméricos / Mesotelioma Maligno / Mesotelina Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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