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Synthesis of Amides via the Amination of Aldehydes with Hydroxylamines Promoted by TBAF·3H2O.
Zhang, Huaiyuan; Xu, Nuo; Su, Botao; Zhang, Jingren; Zhang, Chongen; Zhang, Zhiyuan; Guo, Binbin; Xu, Shengjie; Wang, Shouwei; Tang, Rongping.
Afiliação
  • Zhang H; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Xu N; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Su B; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Zhang J; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Zhang C; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Zhang Z; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Guo B; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Xu S; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Wang S; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
  • Tang R; School of Applied Chemical Engineering, Lanzhou Petrochemical University of Vocational Technology, No. 1 Shandan Street, Lanzhou 730060, P. R. China.
J Org Chem ; 89(11): 7579-7590, 2024 Jun 07.
Article em En | MEDLINE | ID: mdl-38781579
ABSTRACT
A metal-free, mild, and efficient method for the synthesis of amides has been developed from the amination of aldehydes with hydroxylamines promoted by TBAF·3H2O in the presence of KOH. Control experiments showed that the nitrone was the intermediate of this amination. By this method, a series of amides, biologically active compounds bebenil and a COX inhibitor were obtained in moderate to good yields.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article