Understanding the roles of compaction pressure and crystal hardness on powder tabletability through bonding area - Bonding strength interplay.
Int J Pharm
; 659: 124253, 2024 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-38788972
ABSTRACT
Bonding area (BA) and bonding strength (BS) interplay dictates tensile strength of a tablet and, hence, tabletability. Using a series of alkali halides with mechanical properties spanning more than one order of magnitude, the role of compaction pressure and mechanical properties on tabletability is systematically investigated and explained using the BA-BS interplay. Results reveal that BA dominates the BA-BS interplay at low pressures, where more plastic powders attain higher tensile strength due to larger BA. In contrast, BS dominates the interplay at high pressures, when difference in BA between powders is minimized. Under the typical compaction pressures of 100-300 MPa, tablet tensile strength is the highest for materials with intermediate hardness, or plasticity, due to an optimal BA-BS interplay.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pós
/
Pressão
/
Comprimidos
/
Resistência à Tração
/
Dureza
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article