Carbonylative cyclization of biaryl enones with aldehydes and oxamic acids.
Org Biomol Chem
; 22(24): 4901-4911, 2024 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-38832447
ABSTRACT
An oxidative radical-promoted carbonylative cyclization strategy for the synthesis of phenanthren-9-(10H)-one frameworks from biaryl enones using aldehydes as the carbonyl radical sources is disclosed. The reaction proceeds through a sequential addition of a carbonyl radical to the olefin followed by cyclization with an aryl ring. The method is further extended to carbamoyl radicals generated from oxamic acids to access the corresponding phenanthrenones with amide functionalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article