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A survey of isatin hybrids and their biological properties.
Shu, Vanessa Asoh; Eni, Donatus Bekindaka; Ntie-Kang, Fidele.
Afiliação
  • Shu VA; Center for Drug Discovery, Faculty of Science, University of Buea, Buea, Cameroon.
  • Eni DB; Center for Drug Discovery, Faculty of Science, University of Buea, Buea, Cameroon. donatus.bekindaka@ubuea.cm.
  • Ntie-Kang F; Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon. donatus.bekindaka@ubuea.cm.
Mol Divers ; 2024 Jun 04.
Article em En | MEDLINE | ID: mdl-38833124
ABSTRACT
The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitates the urgent development of novel therapeutic candidates that can combat these diseases with efficacy. Molecular hybridization has been established as an efficient technique in designing bioactive molecules capable of fighting infections. Isatin, a core nucleus of an array of compounds with diverse biological properties can be modified at different positions leading to the creation of novel drug targets, is an active area of medicinal chemistry. This review containing published articles from 2005 to 2022 highlights isatin hybrids which have been synthesized and reported in the literature alongside a discussion on their biological properties. The enriched structure-activity relationship studies discussed provides insights for the rational design of novel isatin hybrids with tailored biological properties as effective therapeutic candidates inspired by nature.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article