Spirocerca lupi draft genome, vaccine and anthelmintic targets.
Mol Biochem Parasitol
; 259: 111632, 2024 09.
Article
em En
| MEDLINE
| ID: mdl-38834134
ABSTRACT
Spirocerca lupi is a parasitic nematode affecting predominantly domestic dogs. It causes spirocercosis, a disease that is often fatal. The assembled draft genome of S. lupi consists of 13,627 predicted protein-coding genes and is approximately 150â¯Mb in length. Several known anthelmintic gene targets such as for ß-Tubulin, glutamate, and GABA receptors as well as known vaccine gene targets such as cysteine protease inhibitor and cytokines were identified in S. lupi by comparing orthologs of C. elegans anthelmintic gene targets as well as orthologs to known vaccine candidates. New anthelmintic targets were predicted through an inclusion-exclusion strategy and new vaccine targets were predicted through an immunoinformatics approach. New anthelminthic targets include DNA-directed RNA polymerases, chitin synthase, polymerases, and other enzymes. New vaccine targets include cuticle collagens. These gene targets provide a starting platform for new drug identification and vaccine design.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Thelazioidea
/
Vacinas
/
Genoma Helmíntico
/
Anti-Helmínticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article