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Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer.
Prasad, Rajendra; Jyothi, Vaskuri G S; Kommineni, Nagavendra; Bulusu, Ravi Teja; Mendes, Bárbara B; Lovell, Jonathan F; Conde, João.
Afiliação
  • Prasad R; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh 221005, India.
  • Jyothi VGS; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center (UTHSC), Memphis, Tennessee 38163, United States.
  • Kommineni N; Center for Biomedical Research, Population Council, New York, New York 10065, United States.
  • Bulusu RT; Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida 32307, United States.
  • Mendes BB; NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisbon 1169-056, Portugal.
  • Lovell JF; ToxOmics, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade NOVA de Lisboa, Lisbon, 1169-056, Portugal.
  • Conde J; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United States.
Nano Lett ; 24(27): 8217-8231, 2024 Jul 10.
Article em En | MEDLINE | ID: mdl-38848540
ABSTRACT
Theranostic medicine combines diagnostics and therapeutics, focusing on solid tumors at minimal doses. Optically activated photosensitizers are significant examples owing to their photophysical and chemical properties. Several optotheranostics have been tested that convert light to imaging signals, therapeutic radicals, and heat. Upon light exposure, conjugated photosensitizers kill tumor cells by producing reactive oxygen species and heat or by releasing cancer antigens. Despite clinical trials, these molecularly conjugated photosensitizers require protection from their surroundings and a localized direction for site-specific delivery during blood circulation. Therefore, cell membrane biomimetic ghosts have been proposed for precise and safe delivery of these optically active large molecules, which are clinically relevant because of their biocompatibility, long circulation time, bypass of immune cell recognition, and targeting ability. This review focuses on the role of biomimetic nanoparticles in the treatment and diagnosis of tumors through light-mediated diagnostics and therapy, providing insights into their preclinical and clinical status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Fotossensibilizantes / Materiais Biomiméticos / Nanomedicina Teranóstica / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Fotossensibilizantes / Materiais Biomiméticos / Nanomedicina Teranóstica / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article