Meta-analysis and public policy: Reconciling the evidence on deworming.
Proc Natl Acad Sci U S A
; 121(25): e2308733121, 2024 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-38857387
ABSTRACT
The WHO recommends mass drug administration (MDA) for intestinal worm infections in areas with over 20% infection prevalence. Recent Cochrane meta-analyses endorse treatment of infected individuals but recommend against MDA. We conducted a theory-agnostic random-effects meta-analysis of the effect of multiple-dose MDA and a cost-effectiveness analysis. We estimate significant effects of MDA on child weight (0.15 kg, 95% CI 0.07, 0.24; P < 0.001), mid-upper arm circumference (0.20 cm, 95% CI 0.03, 0.37; P = 0.02), and height (0.09 cm, 95% CI 0.01, 0.16; P = 0.02) when prevalence is over 20% but not on Hb (0.06 g/dL, 95% CI -0.01, 0.14; P = 0.1). These results suggest that MDA is a cost-effective intervention, particularly in the settings where it is recommended by the WHO.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Helmintíase
/
Enteropatias Parasitárias
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article