Synthesis and stability of the [45Ti]Ti-DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals.
Chem Commun (Camb)
; 60(56): 7148-7151, 2024 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-38860653
ABSTRACT
We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid-liquid extraction method, leads to a high radiochemical conversion up to 98%.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Titânio
/
Compostos Radiofarmacêuticos
/
Compostos Heterocíclicos com 1 Anel
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article