Ficini Reaction with Acrylates for the Stereoselective Synthesis of Aminocyclobutanes.
Chemistry
; : e202401810, 2024 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-38869382
ABSTRACT
The first Ficini reaction between ynamides and acrylates is reported herein. The reaction is catalyzed by B(C6F5)3 acting as a Lewis acid and is giving access to stable tri-substituted aminocyclobutenes in high yield. The resulting products can be hydrogenated and epimerized under basic conditions or in presence of a Lewis acid, providing two distinct trans- aminocyclobutane monoester stereoisomers in high yield and diastereoisomeric ratio (up to quantitative yield and >991 dr).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article