The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-omics Mendelian randomization study.
BMC Gastroenterol
; 24(1): 197, 2024 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-38877387
ABSTRACT
BACKGROUND:
Innate/adaptive immunity is the key to anti-tumor therapy. However, its causal relationship to Gastrointestinal (GI) cancer remains unclear.METHODS:
Immunity genes were extracted from the MSigDB database. The Genome-wide association studies (GWAS) summary data of GI cancer were integrated with expression quantitative trait loci (eQTL) and DNA methylation quantitative trait loci (mQTL) associated with genes. Summary-data-based Mendelian randomization (SMR) and co-localization analysis were used to reveal causal relationships between genes and GI cancer. Two-sample MR analysis was used for sensitivity analysis. Single cell analysis clarified the enrichment of genes.RESULTS:
Three-step SMR analysis showed that a putative mechanism, cg17294865 CpG site regulating HLA-DRA expression was negatively associated with gastric cancer risk. HLA-DRA was significantly differentially expressed in monocyte/macrophage and myeloid cells in gastric cancer.CONCLUSION:
This study provides evidence that upregulating the expression level of HLA-DRA can reduce the risk of gastric cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilação de DNA
/
Locos de Características Quantitativas
/
Estudo de Associação Genômica Ampla
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Análise da Randomização Mendeliana
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Imunidade Adaptativa
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Neoplasias Gastrointestinais
/
Imunidade Inata
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article