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Clinical Validation of Digitally Acquired Clinical Data and Machine Learning Models for Remote Measurement of Psoriasis and Psoriatic Arthritis: A Proof-of-Concept Study.
Webster, Dan E; Haberman, Rebecca H; Perez-Chada, Lourdes M; Tummalacherla, Meghasyam; Tediarjo, Aryton; Yadav, Vijay; Neto, Elias Chaibub; MacDuffie, Woody; DePhillips, Michael; Sieg, Eric; Catron, Sydney; Grant, Carly; Francis, Wynona; Nguyen, Marina; Yussuff, Muibat; Castillo, Rochelle L; Yan, Di; Neimann, Andrea L; Reddy, Soumya M; Ogdie, Alexis; Kolivras, Athanassios; Kellen, Michael R; Mangravite, Lara M; Sieberts, Solveig K; Omberg, Larsson; Merola, Joseph F; Scher, Jose U.
Afiliação
  • Webster DE; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Haberman RH; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Perez-Chada LM; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Tummalacherla M; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Tediarjo A; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Yadav V; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Neto EC; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • MacDuffie W; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • DePhillips M; M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA.
  • Sieg E; M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA.
  • Catron S; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Grant C; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Francis W; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Nguyen M; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Yussuff M; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Castillo RL; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Yan D; D. Yan, MD, A.L. Neimann, MD, MSCE, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.
  • Neimann AL; D. Yan, MD, A.L. Neimann, MD, MSCE, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.
  • Reddy SM; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA.
  • Ogdie A; A. Ogdie, MD, MSCE, Department of Medicine, Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Kolivras A; A. Kolivras, MD, PhD, Departments of Dermatology and Dermatopathology, Saint-Pierre, Brugmann and Queen Fabiola Children University Hospitals, Université Libre de Bruxelles, Brussels, and UCB Pharma, Brussels, Belgium.
  • Kellen MR; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Mangravite LM; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Sieberts SK; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Omberg L; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA.
  • Merola JF; J.F. Merola, MD, MMSc, Department of Dermatology and Department of Medicine, Division of Rheumatology, UT Southwestern Medical Center, Dallas, Texas, USA.
  • Scher JU; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA; Jose.Scher@nyulangone.or
J Rheumatol ; 51(8): 781-789, 2024 Aug 01.
Article em En | MEDLINE | ID: mdl-38879192
ABSTRACT

OBJECTIVE:

Psoriatic disease remains underdiagnosed and undertreated. We developed and validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous and musculoskeletal signs and symptoms of psoriatic disease.

METHODS:

Participants with psoriasis (PsO) or psoriatic arthritis (PsA) and healthy controls were recruited between June 5, 2019, and November 10, 2021, at 2 academic medical centers. Concordance and accuracy of digital measures and image-based machine learning models were compared to their analogous clinical measures from trained rheumatologists and dermatologists.

RESULTS:

Of 104 study participants, 51 (49%) were female and 53 (51%) were male, with a mean age of 42.3 years (SD 12.6). Seventy-nine (76%) participants had PsA, 16 (15.4%) had PsO, and 9 (8.7%) were healthy controls. Digital patient assessment of percent body surface area (BSA) affected with PsO demonstrated very strong concordance (Lin concordance correlation coefficient [CCC] 0.94 [95% CI 0.91-0.96]) with physician-assessed BSA. The in-clinic and remote target plaque physician global assessments showed fair-to-moderate concordance (CCCerythema 0.72 [0.59-0.85]; CCCinduration 0.72 [0.62-0.82]; CCCscaling 0.60 [0.48-0.72]). Machine learning models of hand photos taken by patients accurately identified clinically diagnosed nail PsO with an accuracy of 0.76. The Digital Jar Open assessment categorized physician-assessed upper extremity involvement, considering joint tenderness or enthesitis (AUROC 0.68 [0.47-0.85]).

CONCLUSION:

The Psorcast digital assessments achieved significant clinical validity, although they require further validation in larger cohorts before use in evidence-based medicine or clinical trial settings. The smartphone software and analysis pipelines from the Psorcast suite are open source and freely available.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Artrite Psoriásica / Aprendizado de Máquina / Smartphone Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Artrite Psoriásica / Aprendizado de Máquina / Smartphone Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article