Cardiac Transcription Factors and Regulatory Networks.
Adv Exp Med Biol
; 1441: 295-311, 2024.
Article
em En
| MEDLINE
| ID: mdl-38884718
ABSTRACT
Cardiac development is a fine-tuned process governed by complex transcriptional networks, in which transcription factors (TFs) interact with other regulatory layers. In this chapter, we introduce the core cardiac TFs including Gata, Hand, Nkx2, Mef2, Srf, and Tbx. These factors regulate each other's expression and can also act in a combinatorial manner on their downstream targets. Their disruption leads to various cardiac phenotypes in mice, and mutations in humans have been associated with congenital heart defects. In the second part of the chapter, we discuss different levels of regulation including cis-regulatory elements, chromatin structure, and microRNAs, which can interact with transcription factors, modulate their function, or are downstream targets. Finally, examples of disturbances of the cardiac regulatory network leading to congenital heart diseases in human are provided.
Palavras-chave
AVSD; Atrioventricular septal defects; Chromatin structure; Common atrioventricular canal; DNA methylation; DORV; Double outlet right ventricle; Drosophila; ENCODE; Ebstein's anomaly; Embryonic stem cells; Enhancers; FHF; First heart field; GWAS; Gata4GATA binding protein (GATA)GATA4; Genome-wide association studies; HAT; HDAC; Hand1Heart and neural crest derivatives expressed (HAND)HAND1; Hand2Heart and neural crest derivatives expressed (HAND)HAND2; Histone; Isl1; Knockout mice; Left ventricular noncompaction; Mef2; MicroRNAs; MyoD; Myocardin; Nkx2-5; Notch1; Regulatory elements; SCN10A; SCN5A; SHF; Second heart field; Silencers; Srf; TOF; Tbx1; Tbx18T-box (TBX)TBX18; Tbx20T-box (TBX)TBX20; Tbx2T-box (TBX)TBX2; Tbx3T-box (TBX)TBX3; Tbx5; Tead1; Tetralogy of Fallot; Transcription factors; Transcriptional network; Truncus arteriosus; cis-regulatory elements; miR-133; miR-143; miR-145
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Redes Reguladoras de Genes
/
Cardiopatias Congênitas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article