Environmental Signals.
Adv Exp Med Biol
; 1441: 397-416, 2024.
Article
em En
| MEDLINE
| ID: mdl-38884722
ABSTRACT
Environmental factors have long been known to play a role in the pathogenesis of congenital heart disease (CHD), but this has not been a major focus of research in the modern era. Studies of human exposures and animal models demonstrate that demographics (age, race, socioeconomic status), diseases (e.g., diabetes, hypertension, obesity, stress, infection, high altitude), recreational and therapeutic drug use, and chemical exposures are associated with an increased risk for CHD. Unfortunately, although studies suggest that exposures to these factors may cause CHD, in most cases, the data are not strong, are inconclusive, or are contradictory. Although most studies concentrate on the effects of maternal exposure, paternal exposure to some agents can also modify this risk. From a mechanistic standpoint, recent delineation of signaling and genetic controls of cardiac development has revealed molecular pathways that may explain the effects of environmental signals on cardiac morphogenesis and may provide further tools to study the effects of environmental stimuli on cardiac development. For example, environmental factors likely regulate cellular signaling pathways, transcriptional and epigenetic regulation, proliferation, and physiologic processes that can control the development of the heart and other organs. However, understanding of the epidemiology and risk of these exposures and the mechanistic basis for any effects on cardiac development remains incomplete. Further studies defining the relationship between environmental exposures and human CHD and the mechanisms involved should reveal strategies to prevent, diagnose, and treat CHD induced by environmental signals.
Palavras-chave
Alcohol; Chemical exposure; Congenital heart defects; Congenital heart disease; Diabetes; Environmental factors; Folate deficiency; Human demographics; Hypoxia; Hypoxia signaling pathways; Maternal exposure; Maternal infections; Maternal stress; Medications; Mitochondria; Noncoding RNA; Obesity; Oxidative stress; Paternal exposure; Retinoic acid; Rubella infections; Smoke; Teratogens; Thalidomide
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Exposição Ambiental
/
Cardiopatias Congênitas
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article