Retrospective evaluation of the effect of acid suppressant drugs on leukocyte ratios in dogs with mast cell tumors.
J Vet Intern Med
; 38(4): 2305-2315, 2024.
Article
em En
| MEDLINE
| ID: mdl-38888250
ABSTRACT
BACKGROUND:
Acid suppressant drugs (ASDs) are commonly used to decrease gastric acid production, but some evidence exists that ASDs exert immunomodulatory effects. Such an effect has not been investigated in dogs for which ASDs are routinely prescribed.HYPOTHESIS:
Compared to naïve subjects, dogs treated with ASDs will exhibit differences in leukocyte ratios after treatment. ANIMALS Fifty-one dogs with mast cell tumors (MCTs). MATERIALS ANDMETHODS:
Dogs with MCT that were either AS naïve or treated with ASDs (i.e., histamine-2-receptor antagonists [H2RA] or proton pump inhibitors [PPI]) were included in this retrospective study. Subjects were categorized into 3 treatment groups (AS naïve, H2RA treated, and PPI treated), and leukocyte ratios (neutrophileosinophil, lymphocytemonocyte, and neutrophillymphocyte [NLR]) were calculated before and after treatment. A mixed effects analysis of variance on ranks was used to assess differences in ratios between treatments, between pre- and post-treatment time points, and between pre- and post-time points for each treatment. Concurrent administration of antihistamines, corticosteroids, and chemotherapeutic drugs was assessed as a confounding factor.RESULTS:
Famotidine (n = 14/14) and omeprazole (n = 12/12) were the only H2RA and PPI used, respectively. Dogs receiving famotidine had a significant increase in median NLR from pre- to post-treatment (3.429; range, 1.417-15 to 5.631; range, 2.654-92; P < 0.01) compared to PPI treated or AS naïve dogs. No differences existed in chemotherapeutic drug or corticosteroid use between groups.CONCLUSIONS:
A significant difference in NLR was identified in famotidine treated dogs compared with omeprazole treated or AS naïve dogs.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Omeprazol
/
Famotidina
/
Doenças do Cão
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Inibidores da Bomba de Prótons
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Antagonistas dos Receptores H2 da Histamina
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article