A Narrative Review of the Roles of Chondromodulin-I (Cnmd) in Adult Cartilage Tissue.
Int J Mol Sci
; 25(11)2024 May 27.
Article
em En
| MEDLINE
| ID: mdl-38892027
ABSTRACT
Articular cartilage is crucial for joint function but its avascularity limits intrinsic repair, leading to conditions like osteoarthritis (OA). Chondromodulin-I (Cnmd) has emerged as a key molecule in cartilage biology, with potential implications for OA therapy. Cnmd is primarily expressed in cartilage and plays an important role in chondrocyte proliferation, cartilage homeostasis, and the blocking of angiogenesis. In vivo and in vitro studies on Cnmd, also suggest an involvement in bone repair and in delaying OA progression. Its downregulation correlates with OA severity, indicating its potential as a therapeutic target. Further research is needed to fully understand the mode of action of Cnmd and its beneficial implications for managing OA. This comprehensive review aims to elucidate the molecular characteristics of Cnmd, from its expression pattern, role in cartilage maintenance, callus formation during bone repair and association with OA.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Cartilagem Articular
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Peptídeos e Proteínas de Sinalização Intercelular
Limite:
Adult
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Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article