Diffusive lensing as a mechanism of intracellular transport and compartmentalization.
Elife
; 122024 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-38896469
ABSTRACT
While inhomogeneous diffusivity has been identified as a ubiquitous feature of the cellular interior, its implications for particle mobility and concentration at different length scales remain largely unexplored. In this work, we use agent-based simulations of diffusion to investigate how heterogeneous diffusivity affects the movement and concentration of diffusing particles. We propose that a nonequilibrium mode of membrane-less compartmentalization arising from the convergence of diffusive trajectories into low-diffusive sinks, which we call 'diffusive lensing,' is relevant for living systems. Our work highlights the phenomenon of diffusive lensing as a potentially key driver of mesoscale dynamics in the cytoplasm, with possible far-reaching implications for biochemical processes.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoplasma
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article