Get your receptors in a knot with new Wnt signaling agonists.

Wolf, Lucie; Angers, Stephane

Wolf, Lucie; Angers, Stephane.

Afiliação

Wolf L; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
Angers S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy and Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: stephane.angers@utoronto.ca.

Cell Chem Biol ; 31(6): 1044-1046, 2024 Jun 20.

Article em En | MEDLINE | ID: mdl-38906109

ABSTRACT

ABSTRACT

Pharmacological modulation of the Wnt/ß-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth.

Assuntos

Via de Sinalização Wnt; Via de Sinalização Wnt/efeitos dos fármacos; Humanos; Proteínas Wnt/metabolismo; Proteínas Wnt/agonistas; Peptídeos/química; Peptídeos/farmacologia; Peptídeos/metabolismo; beta Catenina/metabolismo; Animais; Receptores Wnt/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Via de Sinalização Wnt Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google