Discovery of a CK2&#945;'-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library.

Mudaliar, Deepti; Mansky, Rachel H; White, Angel; Baudhuin, Grace; Hawkinson, Jon; Wong, Henry; Walters, Michael A; Gomez-Pastor, Rocio

Discovery of a CK2α'-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library.

Mudaliar, Deepti; Mansky, Rachel H; White, Angel; Baudhuin, Grace; Hawkinson, Jon; Wong, Henry; Walters, Michael A; Gomez-Pastor, Rocio.

Afiliação

Mudaliar D; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Mansky RH; Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55414, United States.
White A; Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Baudhuin G; Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Wong H; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Walters MA; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Gomez-Pastor R; Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55414, United States.

ACS Chem Neurosci ; 15(15): 2703-2718, 2024 Aug 07.

Article em En | MEDLINE | ID: mdl-38908003

Assuntos

Trifosfato de Adenosina; Caseína Quinase II; Ensaios de Triagem em Larga Escala; Inibidores de Proteínas Quinases; Caseína Quinase II/antagonistas & inibidores; Caseína Quinase II/metabolismo; Trifosfato de Adenosina/metabolismo; Humanos; Inibidores de Proteínas Quinases/farmacologia; Ensaios de Triagem em Larga Escala/métodos; Regulação Alostérica/efeitos dos fármacos; Sítio Alostérico/efeitos dos fármacos; Animais; Descoberta de Drogas/métodos; Bibliotecas de Moléculas Pequenas/farmacologia

Palavras-chave

CK2α'; CX-4945; Huntington's disease; allosteric inhibitors; kinase inhibitors; neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trifosfato de Adenosina / Caseína Quinase II / Inibidores de Proteínas Quinases / Ensaios de Triagem em Larga Escala Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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