The Epidemiology of Dermatofibrosarcoma Protuberans Incidence, Metastasis, and Death Among Various Population Groups: A SEER Database Analysis.
J Am Acad Dermatol
; 2024 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-38908718
ABSTRACT
BACKGROUND:
Limited information exists regarding the epidemiology, metastasis, and survival of dermatofibrosarcoma protuberans (DFSP).OBJECTIVE:
To measure DFSP incidence and assess metastasis and survival outcomes.METHODS:
Incidence rate, overall and DFSP-specific survival outcomes for primary DFSP tumors contained in the Surveillance, Epidemiology, and End Results registry (SEER) were analyzed via quasi-poisson regression, Cox and competing risk analyses.RESULTS:
DFSP incidence rate was 6.25 (95%CI, 5.93-6.57) cases per million person-years with significantly higher incidence observed among Black individuals than White individuals (8.74 vs 4.53). DSFP with larger tumor size (≥3 cm, Odds ratio,OR,2.24,95%CI,1.62-3.12,p <0.001) and tumors located on the head and neck (OR 4.88, 95%CI, 3.31-7.18, p<0.001), and genitalia OR3.16,95%CI1.17-8.52, p value=0.023) were associated with significantly increased risk of metastasis whereas higher socioeconomic status (SES) was associated with significantly decreased risk of metastasis. Larger tumor size (≥3 cm), regardless of location, and age (≥60) were associated with significantly worse overall and cancer-specific survival.LIMITATIONS:
Retrospective design of SEERCONCLUSION:
DFSP incidence is 2-fold higher among Black than White individuals. The risk of DFSP metastasis is significantly increased with tumor size ≥3 cm and tumors located on head and neck, and genitalia. Larger tumor size (≥ 3cm), regardless of location, and age (≥60) are the most important prognostic indicators for survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article