Frontotemporal lobar degeneration in the "Annual of the Pathological Autopsy Cases in Japan".
J Neurol
; 271(8): 5549-5555, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38909120
ABSTRACT
BACKGROUND:
Good accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has been reported.OBJECTIVE:
To assess the diagnostic accuracy of FTLD in an entire population, without restrictions related to patient age or diagnosing physician.METHODS:
Volumes of the "Annual of the Pathological Autopsy Cases in Japan," with reports of 130,105 autopsies throughout Japan from 2007 to 2016, were descriptively analyzed.RESULTS:
There were 219 patients with clinical and/or pathological diagnoses of FTLD. The sensitivity and specificity were 24.5% and 76.9%, respectively. Age at death for pathologically confirmed patients was 76.3 ± 11.6 years (mean ± standard deviation). Overlooked patients died significantly older than patients with an accurate clinical diagnosis.CONCLUSIONS:
Clinical diagnoses of FTLD had low sensitivity. Furthermore, the age at death of pathologically confirmed patients suggests that FTLD affects a wide age range and is not restricted to presenile individuals.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autopsia
/
Degeneração Lobar Frontotemporal
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article