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Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials.
Witt, Emily; Leach, Alexander J; Bi, Jianling; Hatfield, Samual; Cotoia, Alicia T; McGovern, Megan K; Cafi, Arielle B; Rhodes, Ashley C; Cook, Austin N; Uaroon, Slyn; Parajuli, Bishal; Kim, Jinhee; Feig, Vivian; Scheiflinger, Alexandra; Nwosu, Ikenna; Jimenez, Miguel; Coleman, Mitchell C; Buchakjian, Marisa R; Bosch, Dustin E; Tift, Michael S; Traverso, Giovanni; Otterbein, Leo E; Byrne, James D.
Afiliação
  • Witt E; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Leach AJ; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Bi J; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Hatfield S; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Cotoia AT; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
  • McGovern MK; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Cafi AB; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Rhodes AC; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Cook AN; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Uaroon S; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
  • Parajuli B; Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA.
  • Kim J; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Feig V; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Scheiflinger A; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Nwosu I; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Jimenez M; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Coleman MC; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Buchakjian MR; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Bosch DE; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Tift MS; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
  • Traverso G; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
  • Otterbein LE; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
  • Byrne JD; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Device ; 2(5)2024 May 17.
Article em En | MEDLINE | ID: mdl-38911126
ABSTRACT
Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune modulating effects. To facilitate delivery of CO, we have designed hyaluronic acid-based CO-gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N2-GEMs and untreated controls.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article