Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1âpositive patients with HIV-related dermatoses in Latvia.
Acta Dermatovenerol Alp Pannonica Adriat
; 33(2): 89-94, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38918943
ABSTRACT
INTRODUCTION:
This study explores the immunogenetic associations of human leukocyte antigens (HLA) and the calcium release-activated calcium modulator 1 (ORAI1) and stromal interaction molecule 1 (STIM1) genes in HIV-1âpositive patients with HIV-related skin disorders.METHODS:
This study assessed the distribution of variants of HLA class II alleles and expression levels of ORAI1 and STIM1 genes in the blood between HIV-1âpositive patients with HIV-related skin disorders and the control group with no HIV within the Latvian population.RESULTS:
The research group comprised 115 HIV-1âpositive patients with HIV-related skin disorders, and the control group included 80 healthy individuals. Risk alleles (HLA- DQB1*0201-0301 and HLA-DQA1*0101-0501) and protective alleles (HLA-DRB1*07-13, DRB1*01-13, DRB1*04-11, and HLA-DQA1*0501-0501) showed statistical significance in the groups. In 38 out of 115 patients, higher expression levels of ORAI1 and STIM1 genes were detected in the blood at the beginning of treatment. A significantly higher level of the microribonucleic acid (mRNA) ORAI1 gene was also found in the control group.CONCLUSIONS:
The results demonstrate that HLA class II alleles are associated with a trend toward risk/protection concerning HIV-related skin disorders in HIV-1âpositive patients. It was also shown that a low level of ORAI1 mRNA and the risk allele HLA-DQB1*0201-0301 were simultaneously present in the research group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Infecções por HIV
/
Molécula 1 de Interação Estromal
/
Proteína ORAI1
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article