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A Unified Synthetic Approach to the Pleurotin Natural Products.
Gao, Yong; Xia, Qidong; Zhu, An; Mao, Wenkuan; Mo, Yiming; Ding, Hanfeng; Xuan, Jun.
Afiliação
  • Gao Y; Engineering Research Center of Functional Materials Intelligent Manufacturing of Zhejiang Province, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, China.
  • Xia Q; Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
  • Zhu A; Engineering Research Center of Functional Materials Intelligent Manufacturing of Zhejiang Province, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, China.
  • Mao W; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
  • Mo Y; Engineering Research Center of Functional Materials Intelligent Manufacturing of Zhejiang Province, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, China.
  • Ding H; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
  • Xuan J; Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
J Am Chem Soc ; 146(27): 18230-18235, 2024 Jul 10.
Article em En | MEDLINE | ID: mdl-38920391
ABSTRACT
The asymmetric total syntheses of four pleurotin natural products, namely, (-)-pleurotin, (+)-leucopleurotin, (+)-leucopleurotinic acid, and (+)-dihydropleurotinic acid, were described in a concise manner. Key transformations feature a Johnson-Claisen rearrangement, a diastereo-controlled sequential hydroboration-oxidation, a SOMO/photoredox activated aldehyde α-alkylation, and oxidative cyclizations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article