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Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Sharma, Horrick; Mondal, Somrita; Urquiza, Uzziah; Esparza, Colter; Bartlett, Seth; Santa-Pinter, Landon; Hill, Hanna; White, Madalyn; Sharma, Pragya; Luckett-Chastain, Lerin; Cooper, Anne; Rasel, Mohammad; Gao, Philip; Battaile, Kevin P; Shukla, Surendra K; Lovell, Scott; Ihnat, Michael A.
Afiliação
  • Sharma H; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA. Electronic address: horrick.sharma@swosu.edu.
  • Mondal S; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Urquiza U; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Esparza C; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Bartlett S; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Santa-Pinter L; Department of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Hill H; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • White M; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Sharma P; Department of Biological & Biomedical Sciences, Southwestern Oklahoma State University, Weatherford, OK, USA.
  • Luckett-Chastain L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
  • Cooper A; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
  • Rasel M; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
  • Gao P; Protein Production Group, The University of Kansas, Lawrence, KS, USA.
  • Battaile KP; New York Structural Biology Center, Upton, NY, USA.
  • Shukla SK; Department of Oncology Science, OU College of Medicine, Oklahoma City, USA.
  • Lovell S; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, KS, USA.
  • Ihnat MA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Eur J Med Chem ; 275: 116598, 2024 Sep 05.
Article em En | MEDLINE | ID: mdl-38925013
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proliferação de Células / Inibidores Enzimáticos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proliferação de Células / Inibidores Enzimáticos / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article