Impact of dose volume parameters and clinical characteristics on radiation-induced acute oral mucositis for head and neck cancer patients treated with carbon-ion radiotherapy dose volume outcome analysis.
Strahlenther Onkol
; 2024 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-38926185
ABSTRACT
OBJECTIVES:
To assess the predictive value of different dosimetric parameters for acute radiation oral mucositis (ROM) in head and neck cancer (HNCs) patients treated with carbon-ion radiotherapy (CIRT).METHODS:
44 patients with HNCs treated with CIRT were evaluated for acute ROM which was defined as severe when the score ≥3 (acute ROM was scored prospectively using the Radiation Therapy Oncology Group (RTOG) score system). Predictive dosimetric factors were identified by using univariate and multivariate analysis.RESULTS:
Male gender, weight loss >5%, and total dose/fractions were related factors to severe ROM. In multivariate analysis, grade ≥3 ROM was significantly related to the Dmax, D10, D15, and D20 (Pâ¯< 0.05, respectively). As the receiver operating characteristics (ROC) curve shows, the area under the curve (AUC) for D10 was 0.77 (pâ¯= 0.003), and the cutoff value was 51.06â¯Gy (RBE); The AUC for D15 was 0.75 (pâ¯= 0.006), and the cutoff value was 42.82â¯Gy (RBE); The AUC for D20 was 0.74 (pâ¯= 0.009), and the cutoff value was 30.45â¯Gy (RBE); The AUC for Dmax was 0.81 (pâ¯< 0.001), and the cutoff value was 69.33â¯Gy (RBE).CONCLUSION:
Male gender, weight loss, and total dose/fractions were significantly association with ROM. Dmax, D10, D15 and D20 were identified as the most valuable predictor and we suggest a Dmax limit of 69.33â¯Gy (RBE), D10 limit of 51.06â¯Gy (RBE), D15 limit of 42.82â¯Gy (RBE), and D20 limit of 30.45â¯Gy (RBE) and for oral mucosa.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article