Phosphine-Catalyzed Ring-Opening Regioselective Addition of Cyclopropenones with Amides.
J Org Chem
; 89(14): 10093-10098, 2024 Jul 19.
Article
em En
| MEDLINE
| ID: mdl-38935753
ABSTRACT
A series of amides, including α-bromo hydroxamates, N-alkoxyamides, and N-aryloxyamides, were subjected to phosphine-catalyzed ring-opening O-selective addition with cyclopropenones, producing various special α,ß-unsaturated esters containing oxime ether motif, in moderate to excellent yields, with high regioselectivity, and exclusive O-selectivity. The methodology is highly atom-economical, with simple operation procedures, and compatible with a wide substrate scope (more than 44 examples).
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article