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HNN-core: A Python software for cellular and circuit-level interpretation of human MEG/EEG.
Jas, Mainak; Thorpe, Ryan; Tolley, Nicholas; Bailey, Christopher; Brandt, Steven; Caldwell, Blake; Cheng, Huzi; Daniels, Dylan; Pujol, Carolina Fernandez; Khalil, Mostafa; Kanekar, Samika; Kohl, Carmen; Kolozsvári, Orsolya; Lankinen, Kaisu; Loi, Kenneth; Neymotin, Sam; Partani, Rajat; Pelah, Mattan; Rockhill, Alex; Sherif, Mohamed; Hamalainen, Matti; Jones, Stephanie.
Afiliação
  • Jas M; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Thorpe R; Department of Neuroscience, Brown University, Providence, RI, USA.
  • Tolley N; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Bailey C; Department of Neuroscience, Brown University, Providence, RI, USA.
  • Brandt S; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Caldwell B; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Cheng H; Department of Neuroscience, Brown University, Providence, RI, USA.
  • Daniels D; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Pujol CF; Bassett Medical Center, Cooperstown, NY, USA.
  • Khalil M; Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.
  • Kanekar S; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Kohl C; Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA.
  • Kolozsvári O; Department of Psychiatry and Behavioral Health, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
  • Lankinen K; Warren Alpert Medical, Brown University, Providence, RI.
  • Loi K; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Neymotin S; Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.
  • Partani R; Jyväskylä Centre for Interdisciplinary Brain Research, University of Jyväskylä, Jyväskylä, Finland.
  • Pelah M; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
  • Rockhill A; Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Sherif M; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
  • Hamalainen M; Department of Molecular and Cell Biology; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
  • Jones S; Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Article em En | MEDLINE | ID: mdl-38939123
ABSTRACT
HNN-core is a library for circuit and cellular level interpretation of non-invasive human magneto-/electro-encephalography (MEG/EEG) data. It is based on the Human Neocortical Neurosolver (HNN) software (Neymotin et al., 2020), a modeling tool designed to simulate multiscale neural mechanisms generating current dipoles in a localized patch of neocortex. HNN's foundation is a biophysically detailed neural network representing a canonical neocortical column containing populations of pyramidal and inhibitory neurons together with layer-specific exogenous synaptic drive (Figure 1 left). In addition to simulating network-level interactions, HNN produces the intracellular currents in the long apical dendrites of pyramidal cells across the cortical layers known to be responsible for macroscopic current dipole generation.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article