Causal relationship between primary sclerosing cholangitis and systemic lupus erythematosus: a bidirectional Mendelian randomization study.
Eur J Med Res
; 29(1): 351, 2024 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-38943194
ABSTRACT
BACKGROUND:
Observational studies have found a link between two autoimmune diseases, namely, primary sclerosing cholangitis (PSC) and systemic lupus erythematosus (SLE). However, the relationship remains unclear.METHODS:
Bidirectional Mendelian randomization (MR) analysis and statistical methods, including inverse variance weighting, weighted median, and MR-Egger tests, were performed using data from genome-wide association studies to detect a causal relationship between PSC and SLE. Sensitivity analyses were subsequently performed to assess the robustness of the results. Univariate MR methods were also investigated.RESULTS:
Results of MR analysis suggested that PSC was associated with an increased risk for SLE (odds ratio 1.33, 95% confidence interval 1.10-1.61, P=0.0039) However, SLE had no significant causal relationship with PSC.CONCLUSION:
Results of MR analysis revealed that patients with PSC were at an increased risk for SLE, which provides new insights into the relationship between these two autoimmune diseases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colangite Esclerosante
/
Estudo de Associação Genômica Ampla
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Análise da Randomização Mendeliana
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Lúpus Eritematoso Sistêmico
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article