Back on the chain gang: polyphosphate modification of proteins.

Neville, Nolan; Lehotsky, Kirsten; Jia, Zongchao

Neville, Nolan; Lehotsky, Kirsten; Jia, Zongchao.

Afiliação

Neville N; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Lehotsky K; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada.
Jia Z; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address: jia@queensu.ca.

Trends Biochem Sci ; 49(9): 757-760, 2024 Sep.

Article em En | MEDLINE | ID: mdl-38945730

ABSTRACT

ABSTRACT

Polyphosphate (polyP) mediates a plethora of biological functions. Understanding the polyP-protein interactome will help clarify the mechanisms underpinning these functions. Recent studies demonstrating a strong but noncovalent modification of lysine and histidine repeat proteins by polyP have provided new insights into polyP-protein biochemistry with implications for research and therapeutics.

Assuntos

Polifosfatos; Proteínas; Polifosfatos/metabolismo; Polifosfatos/química; Proteínas/metabolismo; Proteínas/química; Humanos

Palavras-chave

PASK; histidine repeat; lysine repeat; polyphosphate; polyphosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polifosfatos / Proteínas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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