Endogenous Fe2+-triggered self-targeting nanomicelles for self-amplifying intracellular oxidative stress.
Animal Model Exp Med
; 2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38952042
ABSTRACT
BACKGROUND:
Artesunate (ASA) acts as an â¢O2- source through the breakdown of endoperoxide bridges catalyzed by Fe2+, yet its efficacy in ASA-based nanodrugs is limited by poor intracellular delivery.METHODS:
ASA-hyaluronic acid (HA) conjugates were formed from hydrophobic ASA and hydrophilic HA by an esterification reaction first, and then self-targeting nanomicelles (NM) were developed using the fact that the amphiphilic conjugates of ASA and HA are capable of self-assembling in aqueous environments.RESULTS:
These ASA-HA NMs utilize CD44 receptor-mediated transcytosis to greatly enhance uptake by breast cancer cells. Subsequently, endogenous Fe2+ from the tumor catalyzes the released ASA to produce highly toxic â¢O2- radicals to kill tumor cells, although sustained tumor growth inhibition can be achieved via in vivo experiments.CONCLUSIONS:
Self-targeting NMs represent a promising strategy for enhancing ASA-based treatments, leveraging clinically approved drugs to expedite drug development and clinical research in oncology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article